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1

Synthetic Inhibitors of Thrombin and Factor Xa: From Bench to Bedside

Jörg Hauptmann, Jörg Stürzebecher

Journal:

Thrombosis Research

Year:

1999

Language:

english

File:

PDF, 906 KB

english, 1999

2

Experimentelle untersuchungen zum Wirkungsmechanismus des Neurohormons D von Periplaneta americana (L.) am “biologischen Modell” der Harnblase von Bufo bufo (L.)

Manfred Gersch, Klaus Richter, Jörg Stürzebecher, Bärbel Fabian

Journal:

General and Comparative Endocrinology

Year:

1969

File:

PDF, 1015 KB

1969

3

Weitere experimentelle Untersuchungen zum Wirkungsmechanismus des neurohormones D von Periplaneta americana (L.) am “biologischen Modell” der Harnblase von Bufo bufo (L.): Beeinflussung des Na+-transportes

Manfred Gersch, Klaus Richter, Jörg Stürzebecher

Journal:

General and Comparative Endocrinology

Year:

1971

File:

PDF, 510 KB

1971

4

Geometry of binding of the Nα-tosylated piperidides of m-amidino-, p-amidino- and p-guanidino phenylalanine to thrombin and trypsin: X-ray crystal structures of their trypsin complexes and modeling of their thrombin complexes

Dušan Turk, Jörg Stürzebecher, Wolfram Bode

Journal:

Year:

1991

Language:

english

File:

PDF, 801 KB

english, 1991

5

Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues

Tziridis, Anastasia, Rauh, Daniel, Neumann, Piotr, Kolenko, Petr, Menzel, Anja, Bräuer, Ulrike, Ursel, Christian, Steinmetzer, Peter, Stürzebecher, Jörg, Schweinitz, Andrea, Steinmetzer, Torsten, Stub

Journal:

Biological Chemistry

Year:

2014

Language:

english

File:

PDF, 5.40 MB

english, 2014

6

Selective Inhibition of Large-to-Small Surfactant Aggregate Conversion by Serine Protease Inhibitors of the bis-Benzamidine Type

Ruppert, Clemens, Pucker, Carolin, Markart, Philipp, Schmidt, Reinhold, Grimminger, Fritz, Seeger, Werner, Stürzebecher, Jörg, Günther, Andreas

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2003

Language:

english

File:

PDF, 99 KB

english, 2003

7

New Thrombin Inhibitors Based on D-CHA-PRO-Derivatives

Steinmetzer, Torsten, Batdorsdhjin, Mjanganzezeg, Kleinwächter, Peter, Seyfarth, Lydia, Greiner, Georg, Reißmann, Siegmund, Stürzebecher, JÖRg

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 671 KB

english, 1999

8

Crystallographic Determination of Thrombin Complexes With Small Synthetic Inhibitors as a Starting Point for the Receptor-Based Design of Antithrombotics

Bauer, Margit, Brandstetter, Hans, Turk, Dusan, Stürzebecher, Jörg, Bode, Wolfram

Journal:

Seminars in Thrombosis and Hemostasis

Year:

1993

Language:

english

File:

PDF, 1.75 MB

english, 1993

9

Geometry of binding of the benzamidine- and arginine-based inhibitors Nα-(2-naphthyl-sulphonyl-glycyl)-dl-p-amidinophenylalanyl-piperidine (NAPAP) and (2R,4R)-4-methyl-1-[Nα-(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulphonyl)-l-arginyl]-2-piperidine carboxylic acid (MQPA) to human α-thrombin : X-ray crystallographic determination of the NAPAP-trypsin complex and modeling of NAPAP-thrombin and MQPA-thrombin

Wolfram BODE, Dušan TURK, Jörg STÜRZEBECHER

Journal:

Year:

1990

Language:

english

File:

PDF, 825 KB

english, 1990

10

New Bivalent Thrombin Inhibitors with N? (Methyl)Arginine at the P1-Position

Steinmetzer, Torsten, Batdordshjin, Mjanganzezeg, Pineda, Felipe, Seyfarth, Lydia, Vogel, André, Reißmann, Siegmund, Hauptmann, Jörg, Stürzebecher, Jörg

Journal:

Biological Chemistry

Year:

2000

Language:

english

File:

PDF, 175 KB

english, 2000

11

The X-Ray Crystal Structure of Thrombin in Complex with Nα-2-Naphthylsulfonyl-L-3-Amidino-Phenylalanyl-4-Methylpiperidide: The Beneficial Effect of Filling Out an Empty Cavity

Bergner, Andreas, Bauer, Margit, Brandstetter, Hans, Stürzebecher, JÖRg, Bode, Wolfram

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 833 KB

english, 1995

12

Tyr-c[D-Orn-Tyr(Bzl)-Pro-Gly]: a novel antiproliferative acting somatostatin receptor agonist with μ-opioid receptor-sensitizing properties

Jörg Stirnweiss, Bianka Hartrodt, Gisela Greksch, Uta Stürzebecher, Frank-D Böhmer, Klaus Neubert, Claus Liebmann

Journal:

British Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 391 KB

english, 2003

13

Complexation of the Tissue Plasminogen Activator Protease with Benzamidine-type Inhibitors: Interference by the Kringle 2 Module †

Hu, Chih-Kao, Kohnert, Ulrich, Stürzebecher, Jörg, Fischer, Stephan, Llinás, Miguel

Journal:

Year:

1996

Language:

english

File:

PDF, 575 KB

english, 1996

14

In vitro inhibition of matriptase prevents invasive growth of cell lines of prostate and colon carcinoma

Förbs, Diana, Thiel, Stefan, Stella, Maria, Stürzebecher, Anne, Schweinitz, Andrea, Steinmetzer, Torsten, Stürzebecher, Jörg, Uhland, Kerstin

Journal:

International Journal of Oncology

Year:

2005

Language:

english

File:

PDF, 3.15 MB

english, 2005

15

Weitere Untersuchungen zur Kennzeichnung des Aktivationshormons der Insektenhäutung

Manfred Gersch, Jörg Stürzebecher

Journal:

Journal of Insect Physiology

Year:

1968

File:

PDF, 646 KB

1968

16

Blood coagulation and fibrinolysis before and after exhaustive exercise in patients with IDDM

Hilberg, Thomas, Eichler, Evelyn, Gläser, Doreen, Prasa, Dagmar, Stürzebecher, Jörg, Gabriel, Holger

Journal:

Thrombosis and Haemostasis

Year:

2003

Language:

english

File:

PDF, 303 KB

english, 2003

17

Pure eccentric exercise does not activate blood coagulation

Thomas Hilberg, Doreen Gläser, Dagmar Prasa, Jörg Stürzebecher, Holger H. W. Gabriel

Journal:

European Journal of Applied Physiology

Year:

2005

Language:

english

File:

PDF, 186 KB

english, 2005

18

Determination of Activated Factor IX in Factor IX Concentrates with a Chromogenic Substrate

Dagmar Prasa, Jörg Stürzebecher

Journal:

Thrombosis Research

Year:

1998

Language:

english

File:

PDF, 105 KB

english, 1998

19

Trypsinogen activation in rat pancreatic acinar cells hyperstimulated by caerulein

Walter Halangk, Jörg Stürzebecher, Rainer Matthias, Hans-Ulrich Schulz, Hans Lippert

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

1997

Language:

english

File:

PDF, 224 KB

english, 1997

20

3-Amidinophenylalanine-based inhibitors of urokinase

Jörg Stürzebecher, Helmut Vieweg, Torsten Steinmetzer, Andrea Schweinitz, Milton T. Stubbs, Martin Renatus, Peter Wikström

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 314 KB

english, 1999

21

Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition†

Frank Dullweber, Milton T Stubbs, Đorđe Musil, Jörg Stürzebecher, Gerhard Klebe

Journal:

Journal of Molecular Biology

Year:

2001

Language:

english

File:

PDF, 744 KB

english, 2001

22

Design of Benzamidine-Type Inhibitors of Factor Xa

Gabriel, Bernhard, Stubbs, Milton T., Bergner, Andreas, Hauptmann, Jörg, Bode, Wolfram, Stürzebecher, Jörg, Moroder, Luis

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 284 KB

english, 1998

23

Experimentelle stimulierung der zellulären Aktivität der Prothorakaldrüsen von Periplaneta americana durch den Aktivationsfaktor

Manfred Gersch, Jörg Stürzebecher

Journal:

Journal of Insect Physiology

Year:

1970

File:

PDF, 962 KB

1970

24

The Structure of the Human β II-Tryptase Tetramer: Fo(u)r Better or Worse

Christian P. Sommerhoff, Wolfram Bode, Pedro J. B. Pereira, Milton T. Stubbs, Jorg Sturzebecher, Gerd P. Piechottka, Gabriele Matschiner and Andreas Bergner

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 3.01 MB

english, 1999

25

Structure-Activity Relationships of Recombinant Hirudins

Stürzebecher, Jörg, Walsmann, Peter

Journal:

Seminars in Thrombosis and Hemostasis

Year:

1991

Language:

english

File:

PDF, 815 KB

english, 1991

26

4-Amidinobenzylamine-Based inhibitors of urokinase

Sebastian Künzel, Andrea Schweinitz, Siegmund Reißmann, Jörg Stürzebecher, Torsten Steinmetzer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 115 KB

english, 2002

27

The Methyl Group of Nα(Me)Arg-containing Peptides Disturbs the Active-site Geometry of Thrombin, Impairing Efficient Cleavage

Rainer Friedrich, Torsten Steinmetzer, Robert Huber, Jörg Stürzebecher, Wolfram Bode

Journal:

Journal of Molecular Biology

Year:

2002

Language:

english

File:

PDF, 336 KB

english, 2002

28

Geometry of GPPE binding to picrate and to the urokinase type plasminogen activator

Ewa Żesławska, Jörg Stürzebecher, Barbara J. Oleksyn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 374 KB

english, 2007

29

Transport of Peptidomimetic Thrombin Inhibitors with a 3-Amidino-Phenylalanine Structure: Permeability and Efflux Mechanism in Monolayers of a Human Intestinal Cell Line (Caco-2)

Walter Kamm, Jörg Hauptmann, Isabel Behrens, Jörg Stürzebecher, Frank Dullweber, Holger Gohlke, Milton Stubbs, Gerhard Klebe, Thomas Kissel

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 269 KB

english, 2001

30

Influence of Indocyanine Green on Plasma Disappearance and Biliary Excretion of a Synthetic Thrombin Inhibitor of the 3-Amidinophenyl-alanine Piperazide-type in Rats

Jörg Hauptmann, Jörg Stürzebecher

Journal:

Pharmaceutical Research

Year:

1998

File:

PDF, 406 KB

1998

31

Refined 2·3ÅX-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA: A starting point for improving antithrombotics

Hans Brandstetter, Dusan Turk, H. Wolfgang Hoeffken, Doris Grosse, Jörg Stürzebecher, Philip D. Martin, Brian F.P. Edwards, Wolfram Bode

Journal:

Journal of Molecular Biology

Year:

1992

Language:

english

File:

PDF, 4.38 MB

english, 1992

32

Structure-Actmty Relationships of Inhibitors Derived from 3-Amidinophenylalanine

Stürzebecher, JÖRg, Prasa, Dagmar, Wikström, Peter, Vieweg, Helmut

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 609 KB

english, 1995

33

Influence of Structural Variations in Peptidomimetic 4-Amidinophenylalanine-Derived Thrombin Inhibitors on Plasma Clearance and Biliary Excretion in Rats

Jörg Hauptmann, Torsten Steinmetzer, Helmut Vieweg, Peter Wikström, Jörg Stürzebecher

Journal:

Pharmaceutical Research

Year:

2002

Language:

english

File:

PDF, 104 KB

english, 2002

34

Synthesis and Structure−Activity Relationships of Potent Thrombin Inhibitors: Piperazides of 3-Amidinophenylalanine

Stürzebecher, Jörg, Prasa, Dagmar, Hauptmann, Jörg, Vieweg, Helmut, Wikström, Peter

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 237 KB

english, 1997

35

Three-Dimensional Quantitative Structure−Activity Relationship Analyses Using Comparative Molecular Field Analysis and Comparative Molecular Similarity Indices Analysis To Elucidate Selectivity Differences of Inhibitors Binding to Trypsin, Thrombin, and Factor Xa

Böhm, Markus, Stürzebecher, Jörg, Klebe, Gerhard

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 668 KB

english, 1999

36

Inhibition of Human Mast Cell Tryptase by Benzamidine Derivatives

STÜRZEBECHER, Jörg, PRASA, Dagmar, SOMMERHOFF, Christian P.

Journal:

Biological Chemistry Hoppe-Seyler

Year:

1992

File:

PDF, 841 KB

1992

37

The crystal structures of 3-TAPAP in complexes with the urokinase-type plasminogen activator and picrate

Ewa Żesławska, Uwe Jacob, Jörg Stürzebecher, Barbara J. Oleksyn

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 366 KB

english, 2006

38

Urethanyl-3-Amidinophenylalanine Derivatives as Inhibitors of Factor Xa. X-Ray Crystal Structure of a Trypsin/Inhibitor Complex and Modeling Studies

Sperl, Stefan, Bergner, Andreas, Stürzebecher, Jörg, Magdolen, Viktor, Bode, Wolfram, Moroder, Luis

Journal:

Biological Chemistry

Year:

2000

Language:

english

File:

PDF, 440 KB

english, 2000

39

New Substrate Analogue Inhibitors of Factor Xa Containing 4-Amidinobenzylamide as P1 Residue: Part 1

Steinmetzer, Torsten, Sturzebecher, Jorg, Schuster, Oliver, Sturzebecher, Uta, Schweinitz, Andrea, Sturzebecher, Anne

Journal:

Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 252 KB

english, 2006

40

Synthetic Low-Molecular Weight Thrombin Inhibitors: The Ideal Antithrombotic Drug? an Introduction

Stürzebecher, JÖRg, Meier, JÜRg

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 136 KB

english, 1995

41

Synthetic Inhibitors of Serine Proteinases. 22. Inhibition of Acrosin by Benzamidine Derivatives

STÜRZEBECHER, Jörg, MARKWARDT, Fritz

Journal:

Hoppe-Seyler's Zeitschrift für physiologische Chemie

Year:

1980

Language:

english

File:

PDF, 800 KB

english, 1980

42

Expression and Proteolysis of Vascular Endothelial Growth Factor is Increased in Chronic Wounds

Lauer, Gereon, Sollberg, Stephan, Cole, Melanie, Flamme, Ingo, Sturzebecher, Jorg, Mann, Karlheinz, Krieg, Thomas, Eming, Sabine A.

Journal:

The Journal of Investigative Dermatology

Year:

2000

Language:

english

File:

PDF, 807 KB

english, 2000

43

From selective substrate analogue factor Xa inhibitors to dual inhibitors of thrombin and factor Xa. Part 3

Daniel Dönnecke, Andrea Schweinitz, Anne Stürzebecher, Peter Steinmetzer, Maj Schuster, Uta Stürzebecher, Silke Nicklisch, Jörg Stürzebecher, Torsten Steinmetzer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 224 KB

english, 2007

44

Surgery is inadvisable: Massive varicocele due to portal hypertension

HEINRICH SCHULTE-BAUKLOH, JÖRG KÄMMER, RAINER FELFE, BURKARD STÜRZEBECHER, HELMUT H KNISPEL

Journal:

International Journal of Urology

Year:

2005

Language:

english

File:

PDF, 245 KB

english, 2005

45

Trypsin activity is not involved in premature, intrapancreatic trypsinogen activation

Halangk, Walter, Krüger, Burkhard, Ruthenbürger, Manuel, Stürzebecher, Jörg, Albrecht, Elke, Lippert, Hans, Lerch, Markus M.

Journal:

AJP Gastrointestinal and Liver Physiology

Year:

2002

Language:

english

File:

PDF, 359 KB

english, 2002

46

Interactions of Thrombin with Benzamidine-based Inhibitors

STÜRZEBECHER, JÖRG, VIEWEG, HELMUT, WIKSTRÖM, PETER, TURK, DUSAN, BODE, WOLFRAM

Journal:

Biological Chemistry Hoppe-Seyler

Year:

1992

Language:

english

File:

PDF, 664 KB

english, 1992

47

Rationales Design von Thrombinhemmstoffen: Von Fibrinogen und Hirudin zu synthetischen Antikoagulanzien

Torsten Steinmetzer, Jörg Stürzebecher

Journal:

Pharmazie in unserer Zeit

Year:

2004

Language:

german

File:

PDF, 551 KB

german, 2004

48

Novel non-peptide lead structures for bradykinin B2-receptor antagonists

L. Felipe Pineda, Claus Liebmann, Sabine Hensellek, Inge Paegelow, Torsten Steinmetzer, Andrea Schweinitz, Jörg Stürzebecher, Siegmund Reissmann

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2000

Language:

english

File:

PDF, 696 KB

english, 2000

49

Crystals of the urokinase type plasminogen activator variant βc-uPA in complex with small molecule inhibitors open the way towards structure-based drug design

Ewa Zeslawska, Andrea Schweinitz, Annette Karcher, Peter Sondermann, Stefan Sperl, Jörg Stürzebecher, Uwe Jacob

Journal:

Journal of Molecular Biology

Year:

2000

Language:

english

File:

PDF, 686 KB

english, 2000

50

Fibrinogen Magdeburg I: a novel variant of human fibrinogen with an amino acid exchange in the fibrinopeptide A (Aα 9, Leu→Pro)

Michael Meyer, Gerlinde Kutscher, Jörg Stürzebecher, Gabriele Riesener, Gerd Lutze

Journal:

Thrombosis Research

Year:

2003

Language:

english

File:

PDF, 276 KB

english, 2003

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